Addison disease is a disorder which the adrenal gland doesn’t produce enough hormone. They are established superior of the kidney, which make the hormones change your mood, metabolism, tissue function, and how your body reacts to accentuate. Addison’s disease destroys those glands and will cause your body to shut down which normally where it produce the hormones. Cortisol is the class of hormones called and affects almost every organ in the body. It helps to regulate the body to respond to stress and maintain blood pressure which helps to slow the immune system’s inflammatory response and help to balance the effect of insulin in breaking down sugars for energy and regulate the metabolism of proteins, carbohydrates, and fats. The disease commonly affects people who are thirty to fifty years of age. However, it can occur at any age and affects both in men and women. Addison’s disease is caused by trauma to your adrenal glands or when your organs are affected by another medical condition. This is called adrenal insufficiency. There are two types of adrenal insufficiency which are Primary adrenal and secondary adrenal. Primary adrenal occurs through damage to your adrenal glands by an autoimmune disease; when your body attacks its immune system. Other causes of primary adrenal insufficiency such as tuberculosis, cancer, and bleeding of the adrenal glands. Secondary adrenal happens when another disease produces the adrenal glands to stop producing hormones. For example, if there is a difficulty with the pituitary gland, it can cause secondary Addison’s disease. Or, you may develop Addison’s disease if you suddenly stop taking a corticosteroid medicine. Corticosteroids are sometimes performed to treat asthma, allergies, arthritis, cancer, and immune system problems. There are some people with this kind of disease they are taught to give themselves an injection of hydrocortisone during a stressful situation. There might be some possible complications which can occur if people take it too much or too little of the adrenal hormone or left it untreated the risks of having Addison’s disease is having cancer, laparoscopic adrenalectomy, and have an autoimmune disease such as diabetes. Some of the symptoms that occur are the weakness in the muscle, skin variations or hyperpigmentation that is noticeable on areas of the body such as scars, knees, elbows, knuckles, lips, and skin folds. If they are left untreated Addisonian crisis can lead to shock and death. The patient can also suffer from depression, irritability, and desire for salt, and amenorrhea in female patients. Diagnosing on Addison’s disease is most certainly done with biochemical laboratory tests which consist of an injection of ACTH then monitoring the ACTH producing in a patient’s urine and the levels of ACTH in the patient’s blood to see how the person’s body responds to the injection. Physicians canals identify Addison’s disease by insulin-induced hypoglycemia test. Physician maybe also use x-rays to examine the adrenal glands for calcium that drops that may indicate TB. As research Addison’s disease progress new techniques for early treatments for continuing the development. As the oral indication of the Addison’s disease, especially for oral pigmentation which may occur earlier than the skin pigmentation. The dental surgeon may be the first medical professional to find the infection and early examination of the illness that is necessary for proper therapeutic administration.