RM angiogenesis and recurrent spontaneous abortion, and its

is one of the most common abnormalities associated with pregnancy, which in
many cases the cause remains unknown. Studies have shown that defects in the
phenomenon of angiogenesis can lead to this disorder (21). In this
phenomenon, different genes are involved, in which their aberrant expression
can lead to a change in the level of angiogenesis and the delivery of nutrient
to the fetus, consequently, fetus may be aborted (17, 21). In 2016, Zhu
and colleagues analyzed the inhibitory effect of miR-16 on feto-maternal
angiogenesis and recurrent spontaneous abortion, and its association with the expression
of VEGF-A in samples of the villi, decidua, and trophoblast cell lines, and showed
that the miR-16 expression was higher in the villi and decidua, and the direct
target of miR-16 is VEGF-A (19). However, the
expression of these genes in blood samples of the patients has not been studied.

we examined the expression of miR-16 and VEGF-A in both plasma and PBMCs and found
that although higher expression level of miR-16 in the plasma of uRM group compared
with the control group, it was not significant but in PBMCs, its expression
level was statistically significant. Also, in these cells, expression level of VEGF-A
in the uRM group was more than P <.05. thus it can be concluded that there is no significant relationship between mir-16 and vegf-a in mrna levels. this result was incompatible with the study of amirchaghmaghi et al which carried out at protein level. possible exists only levels expression. another investigation we studied expression mir-21 pten pbmcs showed a correlation their so women urm downregulated upregulated respectively. these findings were consistent by tokyol remarkable increase decidua trophoblast cells patients rm also plasma examination revealed decrease similar to el-shorafa considering investigations has shown embryo development associated mechanisms tumor invasion possibility for involvement genes maternal angiogenesis. conducted examine effect on human demonstrated increasing mirna akt signaling pathways are activated leading increased hif-1 vegf enhances angiogenesis recurrent miscarriage occur inversely means reducing nutrient delivery fetus reduced may takes place. although our not significantly altered but accordance studies performed likely its level will significant. therefore further research needed regard proposed model as follows:>

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